The protein encoded by this gene belongs to the integrin
alpha chain family. Integrins are heterodimeric integral membrane
proteins composed of an alpha chain and a beta chain. They mediate
a wide spectrum of cell-cell and cell-matrix interactions, and thus
play a role in cell migration, morphologic development,
differentiation, and metastasis. This protein functions as a
receptor for the basement membrane protein laminin-1. It is mainly
expressed in skeletal and cardiac muscles and may be involved in
differentiation and migration processes during myogenesis. Defects
in this gene are associated with congenital myopathy. Alternatively
spliced transcript variants encoding different isoforms have been
noted for this gene.1) Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Immunogen
This ITGA7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 229-257 amino acids from the N-terminal region of human ITGA7.
Western blot analysis in CEM cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.