Junctophilin-2, JP-2, Junctophilin type 2, JPH2, JP2
Product description
Junctional complexes between the plasma membrane and
endoplasmic/sarcoplasmic reticulum are a common feature of all
excitable cell types and mediate cross talk between cell surface
and intracellular ion channels. The protein encoded by this gene is
a component of junctional complexes and is composed of a C-terminal
hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum
membrane and a remaining cytoplasmic domain that shows specific
affinity for the plasma membrane. This gene is a member of the
junctophilin gene family. Alternative splicing has been observed at
this locus and two variants encoding distinct isoforms are
described.1) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Immunogen
This JPH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 614-643 amino acids from the C-terminal region of human JPH2.
Western blot analysis in ZR-75-1 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.