Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK5 expression is up-regulated by estrogens and progestins. The protein is secreted and may be involved in desquamation in the epidermis.1) Planque, C., et al., Biochem. Biophys. Res. Commun. 329(4):1260-1266 (2005). Michael, I.P., et al., J. Biol. Chem. 280(15):14628-14635 (2005). Ishida-Yamamoto, A., et al., J. Invest. Dermatol. 124(2):360-366 (2005). Brattsand, M., et al., J. Invest. Dermatol. 124(1):198-203 (2005). Caubet, C., et al., J. Invest. Dermatol. 122(5):1235-1244 (2004).
Immunogen
This Kallikrein 5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-174 amino acids from the Central region of human Kallikrein 5.
Western blot analysis in 293 cell line lysates (35ug/lane).
Application
Western blot analysis of anti-KLK5 Pab in mouse brain tissue lysate
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.