Application
Antibody used in IHC on Rhesus macaque spinal cord at 1:300.Application
Antibody used in WB on Human Daudi at 0.2-1 ug/ml.Application
Antibody used in WB on Mouse kidney, brain at 2 ug/ml.| Product Name | KCNN3 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. KCNN3, a member of the KCNN family of potassium channel genes, encodes a protein that is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits.1) Kolski-Andreaco, A., et al., (2004) J. Biol. Chem. 279 (8), 6893-6904. |
| Immunogen | Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human KCNN3. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISA,WB |
| KCNN3 antibody can be used for detection of KCNN3 by ELISA at 1:62500. KCNN3 antibody can be used for detection of KCNN3 by western blot at 2 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000. | |
| Species Reactivity | Dog,Human,Mouse,Rat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | KCNN3 |
|---|---|
| Alternative Names | KCNN3 SK3 hSK3 SKCA3 KCa2.3 |
| Molecular Weight(MW) | 81 kDa, 48 kDa |
Application
Antibody used in IHC on Rhesus macaque spinal cord at 1:300.
Application
Antibody used in WB on Human Daudi at 0.2-1 ug/ml.
Application
Antibody used in WB on Mouse kidney, brain at 2 ug/ml.| Positive Control | 1) Cat. No. 1224 - Daudi Cell Lysate |
|---|---|
| Application Notes | KCNN3 antibody can be used for detection of KCNN3 by ELISA at 1:62500. KCNN3 antibody can be used for detection of KCNN3 by western blot at 2 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000. |
| Form | Liquid |
|---|---|
| Storage Instructions | For short periods of storage (days) store at 4˚C. For longer periods of storage, store KCNN3 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles. |
| Storage Buffer | Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL. |
