Application
Antibody used in WB on Human Jurkat 0.2-1 ug/ml.Application
Antibody used in WB on Hamster at: 1:1000.Application
Antibody used in IHC on Human brain at 5 ug/ml.| Product Name | KCNQ2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by KCNQ2 and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1).The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.1) Soldovieri, M.V., (2006) J. Biol. Chem. 281 (1), 418-428. |
| Immunogen | Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human KCNQ2. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| KCNQ2 antibody can be used for detection of KCNQ2 by ELISA at 1:62500. KCNQ2 antibody can be used for detection of KCNQ2 by western blot at 0.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000. | |
| Species Reactivity | DogHumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | KCNQ2 |
|---|---|
| Alternative Names | KCNQ2 BFNC EBN EBN1 ENB1 HNSPC KCNA11 KV7.2 KVEBN1 BFNS1 EIEE7 |
| Molecular Weight(MW) | 44 kDa, 93 kDa, 94 kDa, 96 kDa, 93 kDa |
Application
Antibody used in WB on Human Jurkat 0.2-1 ug/ml.
Application
Antibody used in WB on Hamster at: 1:1000.
Application
Antibody used in IHC on Human brain at 5 ug/ml.| Positive Control | 1) Cat. No. 1205 - Jurkat Cell Lysate |
|---|---|
| Application Notes | KCNQ2 antibody can be used for detection of KCNQ2 by ELISA at 1:62500. KCNQ2 antibody can be used for detection of KCNQ2 by western blot at 0.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000. |
| Form | Liquid |
|---|---|
| Storage Instructions | For short periods of storage (days) store at 4˚C. For longer periods of storage, store KCNQ2 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles. |
| Storage Buffer | Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL. |
