Immunohistochemistry
Immunohistochemistry with Brain, cerebellum tissue at an antibody concentration of 5ug/ml using anti-KCNQ2 antibodyWestern blot
0.2-1 ug/mlELISA Titer: 1:312500Positive Control: NCI-H226 cell lysate| Product Name | Rabbit anti-KCNQ2 polyclonal antibody - middle region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | BFNC, EBN, EBN1, ENB1, HNSPC, KCNA11, KV7.2, KVEBN1, BFNS1, EIEE7 |
| Immunogen | The immunogen for anti-KCNQ2 antibody: synthetic peptide directed towards the middle region of human KCNQ2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500~1:2000 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | BovineDogHorseHumanMouseRatZebra Fish |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | KCNQ2 |
|---|---|
| Gene Synonyms | BFNC EBN EBN1 ENB1 HNSPC KCNA11 KV7.2 KVEBN1 BFNS1 EIEE7 |
| Gene Full Name | Potassium voltage-gated channel, KQT-like subfamily, member 2 |
| Gene Summary | The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by KCNQ2 and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1).The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. |
| Alternative Names | BFNC EBN EBN1 ENB1 HNSPC KCNA11 KV7.2 KVEBN1 BFNS1 EIEE7 |
| Molecular Weight(MW) | 44kDa |
| Sequence | 393 amino acids |
Immunohistochemistry
Immunohistochemistry with Brain, cerebellum tissue at an antibody concentration of 5ug/ml using anti-KCNQ2 antibody
Western blot
0.2-1 ug/mlELISA Titer: 1:312500Positive Control: NCI-H226 cell lysate| Application Notes | WB:1:500~1:2000 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
