Application
Immunofluorescence of KIR2DS2 in 293 cells with KIR2DS2 antibody at 20 μg/ml.Application
Western blot analysis of KIR2DS2 in 293 cell lysate with KIR2DS2 antibody at (A) 1 and (B) 2 μg/ml.| Product Name | KIR2DS2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 2, KIR2DL3, MHC class I NK cell receptor, Natural killer-associated transcript 5, NKAT5, p58 KIR, p58 natural killer cell receptor clone CL-49, p58 NK receptor |
| Product description | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells (1). The KIR proteins are classified by the number of extracellular immunoglobulin domains and by whether they have a long (L) or short (S) cytoplasmic domain (2,3). KIR proteins are thought to play an important role in regulation of the immune response (3). KIR2DS2 downregulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells and is a receptor on natural killer (NK) cells for HLA-C alleles (3,4).1) Colonna M and Samaridis J. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science 1995; 268:405-8. |
| Immunogen | KIR2DS2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human KIR2DS2. The immunogen is located within the last 50 amino acids of KIR2DS2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IFWB |
| KIR2DS2 antibody can be used for detection of KIR2DS2 by Western blot at 1 - 2 μg/ml. For immunofluorescence start at 20 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | KIR2DS2 |
|---|---|
| Alternative Names | Killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 2 KIR2DL3 MHC class I NK cell receptor Natural killer-associated transcript 5 NKAT5 p58 KIR p58 natural killer cell receptor clone CL-49 p58 NK receptor |
| Molecular Weight(MW) | Predicted: 28, 33, 37 kDa Observed: 34, 42 kDa |
| Sequence Similarities | 2) Cat. No. 17-010 - 293 Cell Slide |
| Tissue Specificity | KIR2DS2 antibody is human specific. Multiple isoforms are known to exist. |
Application
Immunofluorescence of KIR2DS2 in 293 cells with KIR2DS2 antibody at 20 μg/ml.
Application
Western blot analysis of KIR2DS2 in 293 cell lysate with KIR2DS2 antibody at (A) 1 and (B) 2 μg/ml.| Positive Control | 1) Cat. No. 1210 - 293 Cell Lysate |
|---|---|
| Application Notes | KIR2DS2 antibody can be used for detection of KIR2DS2 by Western blot at 1 - 2 μg/ml. For immunofluorescence start at 20 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | KIR2DS2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. |
| Storage Buffer | KIR2DS2 antibody is supplied in PBS containing 0.02% sodium azide. |
