Application
Immunofluorescence of KLK4 in human kidney tissue with KLK4 antibody at 20 μg/mL.Application
Immunohistochemistry of KLK4 in human kidney tissue with KLK4 antibody at 5 μg/mL.Application
Western blot analysis of KLK4 in human kidney tissue lysate with KLK4 antibody at 1 μg/ml.| Product Name | KLK4 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | KLK4 Antibody : ARM1, EMSP, PSTS, AI2A1, EMSP1, KLK-L1, PRSS17, kallikrein, Kallikrein-4, Enamel matrix serine proteinase 1 |
| Product description | Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes having diverse physiological functions (1). Kallikrein 4 (KLK4), also known as prostase or EMSP1 (enamel matrix serine protease 1), contains one peptidase S1 domain and the expression in prostate is regulated by hormone (1,2). Many kallikreins are implicated in carcinogenesis and have potential as novel cancer and other disease biomarkers (3). KLK4 may have additional roles such as functioning as one of the two major enamel proteases identified that process enamel matrix proteins. Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) (4).1) Stephenson SA, Verity K, Ashworth LK, et al. Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3-13.4. J. Biol. Chem. 1999; 274:23210-4. |
| Immunogen | KLK4 antibody was raised against a 15 amino acid peptide near the center of human KLK4. The immunogen is located within amino acids 80 - 130 of KLK4 . |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| KLK4 antibody can be used for detection of KLK4 by Western blot at 1 - 2 μg/ml.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | KLK4 |
|---|---|
| Alternative Names | KLK4 Antibody : ARM1 EMSP PSTS AI2A1 EMSP1 KLK-L1 PRSS17 kallikrein Kallikrein-4 Enamel matrix serine proteinase 1 |
| Molecular Weight(MW) | Predicted: 28 kDa Observed: 31kDa |
| Sequence Similarities | 2) Cat. No. 10-401 - Human Kidney Tissue Slide |
| Tissue Specificity | KLK4 antibody is human specific. At least three isoforms of KLK4 are known to exist. |
Application
Immunofluorescence of KLK4 in human kidney tissue with KLK4 antibody at 20 μg/mL.
Application
Immunohistochemistry of KLK4 in human kidney tissue with KLK4 antibody at 5 μg/mL.
Application
Western blot analysis of KLK4 in human kidney tissue lysate with KLK4 antibody at 1 μg/ml.| Positive Control | 1) Cat. No. 1305 - Human Kidney Tissue Lysate |
|---|---|
| Application Notes | KLK4 antibody can be used for detection of KLK4 by Western blot at 1 - 2 μg/ml.: |
| Form | Liquid |
|---|---|
| Storage Instructions | KLK4 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. |
| Storage Buffer | KLK4 Antibody is supplied in PBS containing 0.02% sodium azide. |
