Plastin-2, L-plastin, LC64P, Lymphocyte cytosolic protein 1, LCP-1, LCP1, PLS2
Product description
Plastins are a family of actin-binding proteins that are
conserved throughout eukaryote evolution and expressed in most
tissues of higher eukaryotes. In humans, two ubiquitous plastin
isoforms (L and T) have been identified. Plastin 1 (otherwise known
as Fimbrin) is a third distinct plastin isoform which is
specifically expressed at high levels in the small intestine. The L
isoform is expressed only in hemopoietic cell lineages, while the T
isoform has been found in all other normal cells of solid tissues
that have replicative potential (fibroblasts, endothelial cells,
epithelial cells, melanocytes, etc.). However, L-plastin has been
found in many types of malignant human cells of non-hemopoietic
origin suggesting that its expression is induced accompanying
tumorigenesis in solid tissues.1) Wabnitz, G.H., et al. Eur. J. Immunol. 40(9):2437-2449(2010)
Immunogen
This LCP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 306-335 amino acids from the Central region of human LCP1.
Western blot analysis in Jurkat cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.