Lethal(2) giant larvae protein homolog 2, HGL, LLGL2
Product description
The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. LLGL2 is a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells.1) Yasumi, M., et al., J. Biol. Chem. 280(8):6761-6765 (2005). Katoh, M., et al., Int. J. Oncol. 24(3):737-742 (2004).
Immunogen
This LLGL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-199 amino acids from the N-terminal region of human LLGL2.
Western Blot at 1:2000 dilution Lane 1: K562 whole cell lysate Lane 2: MCF-7 whole cell lysate Lysates/proteins at 20 ug per lane.
Application Notes
For WB starting dilution is: 1:2000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.