Lysyl oxidase homolog 4, 143-, Lysyl oxidase-like protein 4, Lysyl oxidase-related protein C, LOXL4, LOXC
Product description
This gene encodes a member of the lysyl oxidase gene
family. The prototypic member of the family is essential to the
biogenesis of connective tissue, encoding an extracellular
copper-dependent amine oxidase that catalyses the first step in the
formation of crosslinks in collagens and elastin. A highly
conserved amino acid sequence at the C-terminus end appears to be
sufficient for amine oxidase activity, suggesting that each family
member may retain this function. The N-terminus is poorly conserved
and may impart additional roles in developmental regulation,
senescence, tumor suppression, cell growth control, and chemotaxis
to each member of the family.1) Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Immunogen
This LOXL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 575-603 amino acids from the C-terminal region of human LOXL4.
Western blot analysis in mouse liver tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.