Application
Immunohistochemistry staining of LRP1 in liver tissue using LRP1 Monoclonal Antibody.| Product Name | LRP1 Antibody, Monoclonal |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | LRP1, Apolipoprotein E receptor, CD91 antigen, CD91, A2MR, IGFBP3R, Alpha-2-macroglobulin receptor, TGFBR5, Type V tgf-beta receptor, APOER, APR, LRP, LRP-1 |
| Product description | Suitable for use in Flow Cytometry, Immunohistochemistry, ELISA, Immunoprecipitation and Western Blot. Other applications have not been tested. Recognizes human CD91, a type I membrane protein which is also known as the alpha 2 macroglobulin receptor (alpha 2 MR). Recognizes an epitope in the extracellular region of the 500kD alpha chain. The low-density lipoprotein receptor related protein 1 (LRP1) is a cell surface protein highly expressed in liver that has close structural and biochemical similarities to the LDL receptor. LRP1 strongly binds calcium and mediates the clearance of chylomicron remnants from the plasma. LPR1 was also separately cloned as the alpha-2-macroglobulin receptor (A2MR) and is necessary for the A2M mediated clearance of beta-amyloid 40 and 42 via receptor-mediated endocytosis. LPR1 may undergo cleavage and the small C-terminal intracellular domain may be found in the cytoplasm or the nucleus of cells. |
| Immunogen | LRP1 monoclonal antibody was raised against pufified LRP1 (Human). |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | ELISAFACSIHCIPWB |
| LRP1 antibody can be used in ELISA, and immunohistochemistry starting at 20 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Symbol | LRP1 |
|---|---|
| Alternative Names | LRP1 Apolipoprotein E receptor CD91 antigen CD91 A2MR IGFBP3R Alpha-2-macroglobulin receptor TGFBR5 Type V tgf-beta receptor APOER APR LRP LRP-1 |
| Tissue Specificity | Recognizes an epitope in the extracellular region of the 500kD alpha chain. |
Application
Immunohistochemistry staining of LRP1 in liver tissue using LRP1 Monoclonal Antibody.| Application Notes | LRP1 antibody can be used in ELISA, and immunohistochemistry starting at 20 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For long term storage of LRP1 antibody add glycerol (40-50%) and store at -20 ˚C. For short term store at 4 ˚C. |
| Storage Buffer | PBS, pH 7.4, 0.09% sodium azide. |
