Application
Immunocytochemistry of LRCC19 in K562 cells with LRCC19 antibody at 2.5 μg/mL.Application
Western blot analysis of LRRC19 in K562 cell lysate with LRRC19 antibody at 1 μg/mL.| Product Name | LRRC19 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | LRRC19 Antibody: Leucine-rich repeat-containing protein 19 |
| Product description | LRRC19 Antibody: LRRC19 is a member of the extracellular leucine-rich repeat superfamily, a family of proteins that are thought to have diverse functions such as cell adhesion, signaling, and innate immunity. LRRC19 is closely related to the Toll-like receptors (TLRs), especially TLR3. LRRC19 does not contain a cytoplasmic Toll/IL-1 receptor (TIR) domain, but can activate NF-κB and induce the production of proinflammatory cytokines after stimulation with the TLR3 and other TLR ligands, suggesting that LRRC19 may play a role in the recognition and the response to certain pathogenic microorganisms. LRRC19 has also been suggested to be a potential biomarker for pancreatic tumor sensitivity to the anti-cancer, small molecule Src inhibitor AZD0530.1) Dolan J, Walshe K, Alsbury S, et al. The extracellular leucine-rich repeat superfamily: a comparative survey and analysis of evolutionary relationships and expression patterns. BMC Genomics2007; 8:320. |
| Immunogen | LRRC19 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human LRRC19. The immunogen is located within amino acids 290 - 340 of LRRC19. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAICCIFWB |
| LRRC19 antibody can be used for detection of LRRC19 by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | LRRC19 |
|---|---|
| Alternative Names | LRRC19 Antibody: Leucine-rich repeat-containing protein 19 |
| Sequence Similarities | 2) Cat. No. 17-004 - K-562 Cell Slide |
Application
Immunocytochemistry of LRCC19 in K562 cells with LRCC19 antibody at 2.5 μg/mL.
Application
Western blot analysis of LRRC19 in K562 cell lysate with LRRC19 antibody at 1 μg/mL.| Positive Control | 1) Cat. No. 1204 - K562 Cell Lysate |
|---|---|
| Application Notes | LRRC19 antibody can be used for detection of LRRC19 by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | LRRC19 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | LRRC19 Antibody is supplied in PBS containing 0.02% sodium azide. |
