Application
Western blot analysis of LRRTM2 in SK-N-SH cell lysate with LRRTM2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.Application
Immunofluorescence of LRRTM2 in human brain tissue with LRRTM2 antibody at 20 μg/mL.Application
Immunohistochemistry of LRRTM2 in human brain tissue with LRRTM2 antibody at 2.5 μg/mL.| Product Name | LRRTM2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | LRRTM2 Antibody: KIAA0416, LRRN2, Leucine-rich repeat transmembrane neuronal protein 2, Leucine-rich repeat neuronal 2 protein |
| Product description | LRRTM2 Antibody: The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Each LRRTM protein is a type I transmembrane containing ten extracellular leucine-rich repeats and a short intracellular tail and has a developmentally regulated pattern distinct from all others. LRRTM2 interacts with PSD-95 and regulates the surface expression of AMPA receptors. LRRTM2 also functions as a neurexin ligand, binding both Neurexin 1-alpha and -beta, suggesting that LRRTM2-Neurexin1 interaction plays a critical role in regulatory excitatory synapse development.1) Lauren J, Airaksinen MS, Saarma M, et al. A novel gene family encoding leucine-rich repeat transmembrane protein differentially expressed in the nervous system. Genomics 2003; 81:411-21. |
| Immunogen | LRRTM2 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human LRRTM2. The immunogen is located within the last 50 amino acids of LRRTM2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| LRRTM2 antibody can be used for detection of LRRTM2 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | LRRTM2 |
|---|---|
| Alternative Names | LRRTM2 Antibody: KIAA0416 LRRN2 Leucine-rich repeat transmembrane neuronal protein 2 Leucine-rich repeat neuronal 2 protein |
| Sequence Similarities | 2) Cat. No. 10-301 - Human Brain Tissue Slide |
| Tissue Specificity | LRRTM2 antibody is predicted to not cross-react with other LRRTM family members. |
Application
Western blot analysis of LRRTM2 in SK-N-SH cell lysate with LRRTM2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Application
Immunofluorescence of LRRTM2 in human brain tissue with LRRTM2 antibody at 20 μg/mL.
Application
Immunohistochemistry of LRRTM2 in human brain tissue with LRRTM2 antibody at 2.5 μg/mL.| Positive Control | 1) Cat. No. 1220 - SK-N-SH Cell Lysate |
|---|---|
| Application Notes | LRRTM2 antibody can be used for detection of LRRTM2 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | LRRTM2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | LRRTM2 Antibody is supplied in PBS containing 0.02% sodium azide. |
