Application
Immunohistochemistry of LRRTM3 in human brain tissue with LRRTM3 antibody at 2.5 μg/mLApplication
Immunofluorescence of LRRTM3 in human brain tissue with LRRTM3 antibody at 20 μg/mL.Application
Western blot analysis of LRRTM3 in mouse brain tissue lysate with LRRTM3 antibody at 0.5 μg/mL in (A) the absence and (B) the presence of blocking peptide.| Product Name | LRRTM3 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | LRRTM3 Antibody: Leucine-rich repeat transmembrane neuronal protein 3 |
| Product description | LRRTM3 Antibody: The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Recent evidence suggests that LRRTM3 promotes the processing of amyloid-precursor protein (APP) by the beta-secretase BACE, leading to the proteolytic production of the Abeta42 peptide that is the main component of amyloid plaques. Furthermore, LRRTM3 maps to a region of chromosome 10 linked to both late-onset Alzheimer's disease (AD) and elevated plasma Abeta42 levels, suggesting that LRRTM3 is a functional and positional candidate gene for AD.1) Lauren J, Airaksinen MS, Saarma M, et al. A novel gene family encoding leucine-rich repeat transmembrane protein differentially expressed in the nervous system. Genomics 2003; 81:411-21. |
| Immunogen | LRRTM3 antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of human LRRTM3. The immunogen is located within the last 50 amino acids of LRRTM3. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| LRRTM3 antibody can be used for detection of LRRTM3 by Western blot at 0.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | LRRTM3 |
|---|---|
| Alternative Names | LRRTM3 Antibody: Leucine-rich repeat transmembrane neuronal protein 3 |
| Sequence Similarities | 2) Cat. No. 10-301 - Human Brain Tissue Slide |
| Tissue Specificity | At least two isoforms of LRRTM3 are known to exist; this antibody will only detect the larger isoform. |
Application
Immunohistochemistry of LRRTM3 in human brain tissue with LRRTM3 antibody at 2.5 μg/mL
Application
Immunofluorescence of LRRTM3 in human brain tissue with LRRTM3 antibody at 20 μg/mL.
Application
Western blot analysis of LRRTM3 in mouse brain tissue lysate with LRRTM3 antibody at 0.5 μg/mL in (A) the absence and (B) the presence of blocking peptide.| Positive Control | 1) Cat. No. 1403 - Mouse Brain Tissue Lysate |
|---|---|
| Application Notes | LRRTM3 antibody can be used for detection of LRRTM3 by Western blot at 0.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | LRRTM3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | LRRTM3 Antibody is supplied in PBS containing 0.02% sodium azide. |
