Application
Immunohistochemistry of LZTR2 in mouse kidney tissue with LZTR2 antibody at 5 μg/mL.Application
Western blot analysis of LZTR2 in mouse kidney tissue lysate with LZTR2 antibody at 1 μg/mL.Application
Immunofluorescence of LZTR2 in mouse kidney tissue with LZTR2 antibody at 20 μg/mL.| Product Name | LZTR2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | LZTR2 Antibody: RGPR, LZTR2, SEC16S, PGPR-p117, KIAA1928, RGPR, Protein transport protein Sec16B, Leucine zipper transcription regulator 2, RGPR-p117 |
| Product description | LZTR2 Antibody: LZTR2, also known as RGPR-p117, is a member of the BTB-kelch superfamily and was initially described as a nuclear factor I (NFI) binding protein and transcriptional regulator of the regucalcin gene. LZTR2 is cytoplasmically localized but is thought to translocate to the nucleus, a process mediated by protein kinase C signaling following hormonal stimulation. Recent evidence has suggested that there is a strong correlation of single nucleotide polymorphisms of LZTR2 with obesity in the Japanese population similar to that seen with the TMEM18 gene and the GNPDA2, BDNF, FAIM2, and MC4R genes with obesity in Caucasian populations, suggesting LZTR2 may play a role in metabolism and obesity risk.1) Misawa H and Yamaguchi M. Molecular cloning and sequencing of the cDNA coding for a novel regucalcin gene promoter region-related protein in rat, mouse and human liver. Int. J. Mol. Med.2001; 8:513-20. |
| Immunogen | LZTR2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human LZTR2. The immunogen is located within the last 50 amino acids of LZTR2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| LZTR2 antibody can be used for detection of LZTR2 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | SEC16B |
|---|---|
| Alternative Names | LZTR2 Antibody: RGPR LZTR2 SEC16S PGPR-p117 KIAA1928 RGPR Protein transport protein Sec16B Leucine zipper transcription regulator 2 RGPR-p117 |
| Sequence Similarities | Predicted species reactivity based on immunogen sequence: Bovine: (100%) |
Application
Immunohistochemistry of LZTR2 in mouse kidney tissue with LZTR2 antibody at 5 μg/mL.
Application
Western blot analysis of LZTR2 in mouse kidney tissue lysate with LZTR2 antibody at 1 μg/mL.
Application
Immunofluorescence of LZTR2 in mouse kidney tissue with LZTR2 antibody at 20 μg/mL.| Positive Control | 1) Cat. No. 1405 - Mouse Kidney Tissue Lysate |
|---|---|
| Application Notes | LZTR2 antibody can be used for detection of LZTR2 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | LZTR2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | LZTR2 Antibody is supplied in PBS containing 0.02% sodium azide. |
