Application
Immunofluorescence of LZTS2 in human kidney tissue with LZTS2 antibody at 20 μg/mL.Application
Immunohistochemistry of LZTS2 in human kidney tissue with LZTS2 antibody at 2.5 μg/mL.Application
Western blot analysis of LZTS2 in human kidney tissue lysate with LZTS2 antibody at 1 μg/mL.| Product Name | LZTS2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | LZTS2 Antibody: LAPSER1, KIAA1813, LAPSER1, Leucine zipper putative tumor suppressor 2, Protein LAPSER1, hLZTS2 |
| Product description | LZTS2 Antibody: The leucine zipper putative tumor suppressor 2 (LZTS2, also known as LAPSER1), a member of the LZTS family, is a negative regulator of the Wnt signaling pathway. It represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. LZTS2 is involved in cytokinesis and regulates katanin-mediated microtubule severing and release from the centrosome. LZTS2 may negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. LZTS2 is highly expressed in testis and prostate, but it is deleted in multiple cancers, including prostate tumors, suggesting that LZTS2 acts as a potential tumor suppressor.1) Thyssen G, Li TH, Lehmann L, et al. LZTS2 is a novel beta-catenin-interacting protein and regulates the nuclear export of beta-catenin. Mol. Cell. Biol. 2006; 26:8857-67 |
| Immunogen | LZTS2 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human LZTS2. The immunogen is located within amino acids 80 - 130 of LZTS2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IFIHC-PWB |
| LZTS2 antibody can be used for detection of EPAC1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
|
| Species Reactivity | Mouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | LZTS2 |
|---|---|
| Alternative Names | LZTS2 Antibody: LAPSER1 KIAA1813 LAPSER1 Leucine zipper putative tumor suppressor 2 Protein LAPSER1 hLZTS2 |
| Sequence Similarities | 2) Cat. No. 10-401 - Human Kidney Tissue Slide |
| Tissue Specificity | LZTS2 antibody is predicted to not cross-react with other LZTS family members |
Application
Immunofluorescence of LZTS2 in human kidney tissue with LZTS2 antibody at 20 μg/mL.
Application
Immunohistochemistry of LZTS2 in human kidney tissue with LZTS2 antibody at 2.5 μg/mL.
Application
Western blot analysis of LZTS2 in human kidney tissue lysate with LZTS2 antibody at 1 μg/mL.| Positive Control | 1) Cat. No. 1305 - Human Kidney Tissue Lysate |
|---|---|
| Application Notes | LZTS2 antibody can be used for detection of EPAC1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | LZTS2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | LZTS2 Antibody is supplied in PBS containing 0.02% sodium azide. |
