Methylmalonic aciduria and homocystinuria type C protein, MMACHC
Product description
The exact function of the protein encoded by this gene is
not known, however, its C-terminal region shows similarity to TonB,
a bacterial protein involved in energy transduction for cobalamin
(vitamin B12) uptake. Hence, it is postulated that this protein may
have a role in the binding and intracellular trafficking of
cobalamin. Mutations in this gene are associated with methylmalonic
aciduria and homocystinuria type cblC.1) Froese, D.S., et al. Mol. Genet. Metab. 100(1):29-36(2010)
Immunogen
This MMACHC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-267 amino acids from the C-terminal region of human MMACHC.
Western blot analysis in K562 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.