Proteins of the matrix metalloproteinase (MMP) family are
involved in the breakdown of extracellular matrix in normal
physiological processes, such as embryonic development,
reproduction, and tissue remodeling, as well as in disease
processes, such as arthritis and metastasis. Most MMP's are
secreted as inactive proproteins which are activated when cleaved
by extracellular proteinases. The encoded protein degrades type IV
collagen, fibronectin, fibrinogen, casein, vitronectin, alpha
1-antitrypsin, alpha 2-macroglobulin, and insulin-like growth
factor-binding protein 1, and activates MMP9 by cleavage. The
protein differs from most MMP family members in that it lacks a
conserved C-terminal protein domain.1) de Amorim, R.F., et al. Acta Odontol. Scand. 68(4):228-231(2010)
Immunogen
This MMP26 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-125 amino acids from the Central region of human MMP26.
Western blot analysis in HL-60 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.