Application
Immunohistochemistry of MORF4 in human brain tissue with MORF4 antibody at 5 μg/mL.Application
Immunofluorescence of MORF4 in HepG2 cells with MORF4 antibody at 20 μg/mL.Application
Western blot analysis of MORF4 in K562 cell lysate with MORF4 antibody at (A) 1 and (B) 2 μg/mL.| Product Name | MORF4 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MORF4 Antibody: CSR, SEN, CSRB, SEN1 |
| Product description | MORF4 Antibody: Cellular senescence is the terminal non-dividing state that normal cells enter following completion of their proliferative potential. Fusions of immortal human cell lines with each other have led to their assignment to one of four complementation groups. Mortality factor 4 (MORF4) was identified as the lead member of a family of transcription factor-like proteins that reverses this immortal phenotype. Like other members in this family, MORF4 is localized to the nucleus and possesses transcription factor-like motifs such as helix-loop-helix and a leucine zipper motif that might allow it to form transcriptionally active homo- or heterodimers. MORF4 has been shown to bind to the transcription corepressors mSin3A and TLE, suggesting that together, these complexes may play a role in transcriptional repression of genes that lead to cellular senescence.1) Pereira-Smith OM and Smith JR. Genetic analysis of indefinite division in human cells: identification of four complementation groups. Proc. Natl. Acad. Sci. USA1988; 85:6042-6. |
| Immunogen | MORF4 antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human MORF4. The immunogen is located within amino acids 20 - 70 of MORF4. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| MORF4 antibody can be used for the detection of MORF4 by Western blot at 1 and 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | MORF4 |
|---|---|
| Alternative Names | MORF4 Antibody: CSR SEN CSRB SEN1 |
| Sequence Similarities | 4) Cat. No. 17-011 - Hep G2 Cell Slide |
Application
Immunohistochemistry of MORF4 in human brain tissue with MORF4 antibody at 5 μg/mL.
Application
Immunofluorescence of MORF4 in HepG2 cells with MORF4 antibody at 20 μg/mL.
Application
Western blot analysis of MORF4 in K562 cell lysate with MORF4 antibody at (A) 1 and (B) 2 μg/mL.| Positive Control | 1) Cat. No. 1204 - K562 Cell Lysate |
|---|---|
| Application Notes | MORF4 antibody can be used for the detection of MORF4 by Western blot at 1 and 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | MORF4 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | MORF4 Antibody is supplied in PBS containing 0.02% sodium azide. |
