Irak4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Phosphorylates IRAK1 (By similarity).1) Erdman, L.K., et al. J. Immunol. 183(10):6452-6459(2009)
Immunogen
This Mouse Irak4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 422-449 amino acids from the C-terminal region of mouse Irak4.
Western blot analysis in MDA-MB435 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.