Application
Western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the detected the Mouse Rnasel protein (arrow).Application
Western blot analysis in mouse spleen tissue lysates (35ug/lane).| Product Name | Rnasel Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | 2-5A-dependent ribonuclease, 2-5A-dependent RNase, 3126-, Ribonuclease 4, Ribonuclease L, RNase L, Rnasel, Rns4 |
| Product description | Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover (By similarity).1) Ireland, D.D., et al. PLoS Pathog.(10), E1000602 (2009) : |
| Immunogen | This Mouse Rnasel antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-167 amino acids from the N-terminal region of mouse Rnasel. |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| For WB starting dilution is: 1:1000: |
|
| Species Reactivity | Mouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | Rnasel |
|---|---|
| Alternative Names | 2-5A-dependent ribonuclease 2-5A-dependent RNase 3126- Ribonuclease 4 Ribonuclease L RNase L Rnasel Rns4 |
| Molecular Weight(MW) | 83 kDa |
Application
Western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the detected the Mouse Rnasel protein (arrow).
Application
Western blot analysis in mouse spleen tissue lysates (35ug/lane).| Application Notes | For WB starting dilution is: 1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Supplied in PBS with 0.09% (W/V) sodium azide. |
