Application
Immunohistochemistry staining of MST1R in colon, surface epithelium tissue using MST1R Antibody.| Product Name | MST1R Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MST1R, C-met-related tyrosine kinase, CD136, CDw136, CD136 antigen, Friend virus susceptibility 2, Fv2, MSP receptor, p185-Ron, PTK8 protein tyrosine kinase 8, RON, Soluble RON variant 3, Soluble RON variant 1, MST1R variant RON30, Oncogene RON, PTK8, MST1 |
| Product description | MST1R/Ron, a HGF Receptor/MET-type protein kinase, mediates the biological activities of macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers. |
| Immunogen | MST1R antibody was raised against a peptide located near the internal domain of MST1R (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIHC |
| MST1R antibody can be used in immunohistochemistry starting at 20 μg/mL.: |
|
| Species Reactivity | GibbonHuman |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | MST1R |
|---|---|
| Alternative Names | MST1R C-met-related tyrosine kinase CD136 CDw136 CD136 antigen Friend virus susceptibility 2 Fv2 MSP receptor p185-Ron PTK8 protein tyrosine kinase 8 RON Soluble RON variant 3 Soluble RON variant 1 MST1R variant RON30 Oncogene RON PTK8 MST1 |
| Tissue Specificity | BLAST analysis of the peptide immunogen showed no homology with other human proteins, except FANCE (50%). |
Application
Immunohistochemistry staining of MST1R in colon, surface epithelium tissue using MST1R Antibody.| Application Notes | MST1R antibody can be used in immunohistochemistry starting at 20 μg/mL.: |
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| Form | Liquid |
|---|---|
| Storage Instructions | MST1R antibody should be stored long term (months) at -80 ˚C and short term (days) at 4 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.1% sodium azide. |
