| Gene Symbol |
MST1R
|
| Gene Synonyms |
RON SEA PTK8 CD136 NPCA3 CDw136 p185-Ron |
| Gene Full Name |
macrophage stimulating 1 receptor |
| Gene Summary |
This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016] |
| Alternative Names |
c met related tyrosine kinase CD136 CD136 antigen CDw136 Macrophage stimulating 1 receptor (c met related tyrosine kinase) Macrophage stimulating 1 receptor Macrophage stimulating protein receptor alpha chain MACROPHAGE STIMULATING PROTEIN RECEPTOR Macrophage stimulating protein receptor beta chain Macrophage-Stimulating 1 Receptor (MST1R) Macrophage-stimulating protein receptor beta chain MSP receptor Mst1r MST1R variant RON30 MST1R variant RON62 NPCA3 p185 RON p185-Ron Protein-tyrosine kinase 8 PTK 8 ptk8 PTK8 protein tyrosine kinase 8 Recepteur d’origine nantais (RON) RON RON protein tyrosine kinase RON variant E2E3 RON_HUMAN Soluble RON variant 1 Soluble RON variant 2 Soluble RON variant 3 Soluble RON variant 4 Stem cell derived tyrosine kinase
|
| Molecular Weight(MW) |
152 kDa |
| Cellular Localization |
Membrane |