This gene encodes a cystoskeletal protein which plays a
significant role in the stability of thin filaments during muscle
contraction. This protein binds F-actin, crosslinks actin
filaments, and prevents latrunculin A-induced filament disassembly.
Mutations in this gene have been associated with limb-girdle
muscular dystrophy and myofibrillar myopathies. Several
alternatively spliced transcript variants of this gene have been
described, but the full-length nature of some of these variants has
not been determined.1) Bailey, S.D., et al. Diabetes Care (2010) In press :
Immunogen
This MYOT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-155 amino acids from the Central region of human MYOT.
Western blot analysis in CEM cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.