Application
Immunohistochemistry of NALP10 in human brain tissue with NALP10 antibody at 10 μg/mL.Application
Immunofluorescence of NALP10 in human brain tissue with NALP10 antibody at 20 μg/mL.Application
Western blot analysis of NALP10 in human brain tissue lysate with NALP10 antibody at 1 μg/mL.| Product Name | NALP10 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | NALP10 Antibody: NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP10 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It was initially identified as PYNOD, an Apaf-1-like protein that binds to ASC, caspase-1 and IL-1β, inhibiting the autoprocessing of caspase-1, caspase-1-mediated IL-1β processing, and ASC aggregation. NALP10 is thus a potent regulator of apoptosis and inflammation.1) Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol.2003; 4:95-104. |
| Immunogen | NALP10 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human NALP10. The immunogen is located within the first 50 amino acids of NALP10. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| NALP10 antibody can be used for detection of NALP10 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL. | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | NLRP10 |
|---|---|
| Alternative Names | NALP10 Antibody: NOD8 PAN5 PYNOD NALP10 CLR11.1 NOD8 NACHT LRR and PYD domains-containing protein 10 Nucleotide-binding oligomerization domain protein 8 |
| Sequence Similarities | 2) Cat. No. 10-301 - Human Brain Tissue Slide |
Application
Immunohistochemistry of NALP10 in human brain tissue with NALP10 antibody at 10 μg/mL.
Application
Immunofluorescence of NALP10 in human brain tissue with NALP10 antibody at 20 μg/mL.
Application
Western blot analysis of NALP10 in human brain tissue lysate with NALP10 antibody at 1 μg/mL.| Positive Control | 1) Cat. No. 1303 - Human Brain Tissue Lysate |
|---|---|
| Application Notes | NALP10 antibody can be used for detection of NALP10 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL. |
| Form | Liquid |
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| Storage Instructions | NALP10 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | NALP10 Antibody is supplied in PBS containing 0.02% sodium azide. |
