Application
Western blot analysis of NALP2 in PC-3 cell lysate with NALP2 antibody at (A) 1 and (B) 2 μg/mL.| Product Name | NALP2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | NALP2 Antibody: NALP2 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli. Unlike the prototypical NALP protein NALP1, NALP2 only contains a NACHT domain, leucine rich repeat (LRR), and pyrin-containing domain (PYD). This protein interacts with the adapter protein ASC in addition to CARD8 and caspase-1 to form an inflammasome with high proIL-1β-processing activity and is thought to function as a modulator of NF-κB and procaspase-1 activation in macrophages. It has also been suggested that NALP2, in addition to other NALP family members, can act as innate sensors of pathogens in a manner similar to the toll-like receptors (TLRs). At least two alternatively spliced transcript variants encoding distinct isoforms have been found for NALP2.1) Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol. 2003; 4:95-104. |
| Immunogen | NALP2 antibody was raised against a peptide corresponding to 12 amino acids near the carboxy terminus of human NALP2. The immunogen is located within the last 50 amino acids of NALP2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| NALP2 antibody can be used for detection of NALP2 by Western blot at 1 to 2 μg/mL. | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | NLRP2 |
|---|---|
| Alternative Names | NALP2 Antibody: NBS1 PAN1 NALP2 PYPAF2 CLR19.9 NBS1 NACHT LRR and PYD domains-containing protein 2 Nucleotide-binding site protein 1 |
Application
Western blot analysis of NALP2 in PC-3 cell lysate with NALP2 antibody at (A) 1 and (B) 2 μg/mL.| Positive Control | 1) Cat. No. 1216 - PC-3 Cell Lysate |
|---|---|
| Application Notes | NALP2 antibody can be used for detection of NALP2 by Western blot at 1 to 2 μg/mL. |
| Form | Liquid |
|---|---|
| Storage Instructions | NALP2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | NALP2 Antibody is supplied in PBS containing 0.02% sodium azide. |
