Application
Western blot analysis of lysed extracts from Mouse Brain tissue using NMDAR1 (Phospho-Ser896).| Product Name | NMDAR1 (phospho Ser896) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | NR1, MRD8, GluN1, NMDA1, NMDAR1, BBC6, BCL2L8, GLURZ1, GRIN1, NMD-R1, NMDZ1, NMZ1 |
| Product description | NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.1) Tyszkiewicz JP, et al. J Physiol. 2004 Feb 1; 554 (Pt 3): 765-777 |
| Immunogen | NMDAR1 (Phospho-Ser896) antibody was raised against a peptide sequence around phosphorylation site of serine 896 (R-R-S (p) -S-K) derived from Human NMDAR1. |
| Modification | p-Ser896 |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | WB |
| Western Blot: 1:500~1:1000: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | GRIN1 |
|---|---|
| Alternative Names | NR1 MRD8 GluN1 NMDA1 NMDAR1 BBC6 BCL2L8 GLURZ1 GRIN1 NMD-R1 NMDZ1 NMZ1 |
| Molecular Weight(MW) | 120 kDa |
| Tissue Specificity | This antibody detects endogenous level of NMDAR1 only when phosphorylated at serine896. |
| Entrez Gene | 2902 |
|---|---|
| Protein Accession | NP_000823.4 |
Application
Western blot analysis of lysed extracts from Mouse Brain tissue using NMDAR1 (Phospho-Ser896).| Application Notes | Western Blot: 1:500~1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
