The protein encoded by this gene is located in the nuclear
envelope. It has protein similarity to nuclear transport factor 2.
This protein functions as a nuclear export factor in both RAN
(Ras-related nuclear protein)- and CRM1 (required for chromosome
region maintenance)-dependent pathways. It is found to stimulate
the export of U1 snRNA in RAN- and CRM1-dependent pathways and the
export of tRNA and mRNA in a CRM1-independent pathway. The encoded
protein heterodimerizes with Tap protein and may regulate the
ability of Tap protein to mediate nuclear mRNA export. The use of
alternate polyadenylation sites has been found for this gene.1) Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Immunogen
This NXT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-111 amino acids from the C-terminal region of human NXT1.
Western blot analysis in mouse liver tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.