This gene encodes a member of the IgLON subfamily in the
immunoglobulin protein superfamily. The encoded protein is
localized in the plasma membrane and may have an accessory role in
opioid receptor function. This gene has an ortholog in rat and
bovine. The opioid binding-cell adhesion molecule encoded by the
rat gene binds opioid alkaloids in the presence of acidic lipids,
exhibits selectivity for mu ligands and acts as a GPI-anchored
protein. Since the encoded protein is highly conserved in species
during evolution, it may have a fundamental role in mammalian
systems. Two transcript variants encoding different isoforms have
been found for this gene.1) Bailey, S.D., et al. Diabetes Care (2010) In press :
Immunogen
This OPCML antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-200 amino acids from the Central region of human OPCML.
Western blot analysis in 293 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.