This gene encodes a protein that is highly expressed in
osteosarcomas. This protein binds to the hypoxia-inducible factor 1
(HIF-1), a key regulator of the hypoxic response and angiogenesis,
and promotes the degradation of one of its subunits. Alternate
transcriptional splice variants, encoding different isoforms, have
been characterized.1) Feng, T., et al. Hum. Genet. 128(3):269-280(2010)
Immunogen
This OS9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-549 amino acids from the C-terminal region of human OS9.
Western blot analysis in U937 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.