Application
Immunohistochemistry staining of P4HB in small intestine: formlin-fixed paraffin-embedded (ffpe)P4HB Antibody.| Product Name | P4HB Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | P4HB, ERBA2L, DSI, GIT, p4HB, p4Hbeta, PDIA1, PHDB, PO4DB, PROHB, Protocollagen hydroxylase, Protein disulfide-isomerase, PO4HB, PDI |
| Product description | This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. |
| Immunogen | P4HB antibody was raised against a synthetic peptide derived from the sequence around Pro329 of P4HB (Human). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ICCIFIHCWB |
| P4HB antibody can be used in immunohistochemistry starting at 10 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | P4HB |
|---|---|
| Alternative Names | P4HB ERBA2L DSI GIT p4HB p4Hbeta PDIA1 PHDB PO4DB PROHB Protocollagen hydroxylase Protein disulfide-isomerase PO4HB PDI |
| Tissue Specificity | Recognizes endogenous levels of total human PDI protein. |
Application
Immunohistochemistry staining of P4HB in small intestine: formlin-fixed paraffin-embedded (ffpe)P4HB Antibody.| Application Notes | P4HB antibody can be used in immunohistochemistry starting at 10 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | P4HB antibody should be stored long term (months) at -20 ˚C and short term (weeks) at 4 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | Supplied as a liquid in 10 mM sodium HEPES, pH 7.5, 150 mM sodium chloride, 0.1 mg/mL BSA, 50% glycerol. |
