Application
Western blot analysis of PACS1 in rat bladder tissue lysate with PACS1 antibody at 1 μg/ml.Application
Immunofluorescence of PACS1 in human bladder tissue with PACS1 antibody at 20 μg/mL.| Product Name | PACS1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Phosphofurin acidic cluster sorting protein 1, PACS-1, MRD17 |
| Product description | The phosphofurin acidic cluster sorting protein 1 (PACS1), belongs to the PACS family of cytosolic connector proteins that localize different membrane proteins to the trans-Golgi network (TGN) (1,2). Mutations in PACS1 cause defects in cranial-neural crest migration during early development, leading to a recognizable intellectual disability syndrome (3). PACS1, along with the related protein PACS2, also plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance (4).1) Wan L, Molloy SS, Thomas L, et al. PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization. Cell 1998; 94:205-16. |
| Immunogen | PACS1 antibody was raised against a 17 amino acid peptide near the center of human PACS1. The immunogen is located within amino acids 430 - 480 of PACS1. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFWB |
| PACS1 antibody can be used for detection of PACS1 by Western blot at 1 - 2 μg/ml. For immunofluorescence start at 20 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | PACS1 |
|---|---|
| Alternative Names | Phosphofurin acidic cluster sorting protein 1 PACS-1 MRD17 |
| Molecular Weight(MW) | Predicted: 106 kDa Observed: 105 kDa |
| Tissue Specificity | PACS1 antibody is human, mouse and rat reactive. Multiple isoforms of PACS1 are known to exist. PACS1 antibody is predicted to not cross-react with PACS2. |
Application
Western blot analysis of PACS1 in rat bladder tissue lysate with PACS1 antibody at 1 μg/ml.
Application
Immunofluorescence of PACS1 in human bladder tissue with PACS1 antibody at 20 μg/mL.| Positive Control | 1) Cat. No. 1478 - Rat Bladder Tissue Lysate |
|---|---|
| Application Notes | PACS1 antibody can be used for detection of PACS1 by Western blot at 1 - 2 μg/ml. For immunofluorescence start at 20 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | PACS1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. |
| Storage Buffer | PACS1 antibody is supplied in PBS containing 0.02% sodium azide. |
