This gene encodes platelet-activating factor
acetylhydrolase isoform 2, a single-subunit intracellular enzyme
that catalyzes the removal of the acetyl group at the SN-2 position
of platelet-activating factor (identified as
1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this
lipase exhibits a broader substrate specificity than simply
platelet activating factor. Two other isoforms of intracellular
platelet-activating factor acetylhydrolase exist, and both are
multi-subunit enzymes. Additionally, there is a single-subunit
serum isoform of this enzyme.1) Schmidt, E.B., et al. Atherosclerosis 196(1):420-424(2008)
Immunogen
This PAFAH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 249-276 amino acids from the Central region of human PAFAH2.
Western blot analysis in MDA-MB453 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.