Application
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma; HC = hepatocarcinoma.Application
PARK8 (LRRK2)Antibody (L899) detect over-expressed human LRRK2 protein.Application
Western blot analysis of PARK8 (LRRK2) using rabbit polyclonal PARK8 (LRRK2)Antibody (L899). (A) 293 cell lysate (2 ug) transiently transfected with the PARK8 gene. (B) Mouse brain lysates (35ug/lane). PARK8 was detected using the purified polyclonal antibody.| Product Name | PARK8 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Leucine-rich repeat serine/threonine-protein kinase 2, Dardarin, LRRK2, PARK8 |
| Product description | Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson's disease identified to date. LRRK2, a genetic mutation, was recently found linked to about 5 percent of inherited cases of Parkinson's disease. By high-resolution recombination mapping and candidate gene sequencing in 46 families, 6 disease-segregating mutations (5 missense and 1 putative splice site mutation). It may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism. LRRK2 belongs to the ROCO protein family and includes a protein kinase domain of the MAPKKK class and several other major functional domains.1) Shen J. Neuron. 2004. 44:575. |
| Immunogen | This PARK8(LRRK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 931-962 amino acids from human PARK8(LRRK2). |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | IHC-PWB |
| For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:50~100: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Symbol | LRRK2 |
|---|---|
| Alternative Names | Leucine-rich repeat serine/threonine-protein kinase 2 Dardarin LRRK2 PARK8 |
| Molecular Weight(MW) | 286 kDa |
Application
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma; HC = hepatocarcinoma.
Application
PARK8 (LRRK2)Antibody (L899) detect over-expressed human LRRK2 protein.
Application
Western blot analysis of PARK8 (LRRK2) using rabbit polyclonal PARK8 (LRRK2)Antibody (L899). (A) 293 cell lysate (2 ug) transiently transfected with the PARK8 gene. (B) Mouse brain lysates (35ug/lane). PARK8 was detected using the purified polyclonal antibody.| Application Notes | For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:50~100: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Supplied in PBS with 0.09% (W/V) sodium azide. |
