Parp2 is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.1) Brunyanszki, A., et al. J. Invest. Dermatol. 130(11):2629-2637(2010)
Immunogen
This PARP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 306-336 amino acids from the C-terminal region of human PARP2.
Western blot analysis in mouse heart tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.