Polycomb group RING finger protein 6, Mel18 and Bmi1-like RING finger, RING finger protein 134, PCGF6, MBLR, RNF134
Product description
The protein encoded by this gene contains a RING finger
motif, which is most closely related to those of polycomb group
(PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to
form protein complexes and function as transcription repressors.
This protein has been shown to interact with some PcG proteins and
act as a transcription repressor. The activity of this protein is
found to be regulated by cell cycle dependent phosphorylation.
Alternatively spliced transcript variants encoding different
isoforms have been identified.1) Lee, J.Y., et al. Cancer Res. 68(11):4201-4209(2008)
Immunogen
This PCGF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 190-217 amino acids from the Central region of human PCGF6.
Western blot analysis in NCI-H292,rat liver,stomach and testis cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.