Cyclic nucleotides are important second messengers that
regulate and mediate a number of cellular responses to
extracellular signals, such as hormones, light, and
neurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs)
regulate the cellular concentrations of cyclic nucleotides and
thereby play a role in signal transduction. PDE4A is a class IV
cAMP-specific PDE (summary by Milatovich et al., 1994 [PubMed
8009369]).1) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Immunogen
This PDE4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human PDE4A.
Western blot analysis in mouse cerebellum tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.