This gene encodes a member of the phospholipase C family,
which catalyze the hydrolysis of phosphatidylinositol
4,5-bisphosphate to generate the second messengers diacylglycerol
and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3
mediate a variety of cellular responses to extracellular stimuli by
inducing protein kinase C and increasing cytosolic Ca(2+)
concentrations. This enzyme localizes to the plasma membrane and
requires calcium for activation. Its activity is inhibited by
spermine, sphingosine, and several phospholipids. [provided by
RefSeq].1) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Immunogen
This PLCD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 60-89 amino acids from the N-terminal region of human PLCD3.
Western blot analysis in mouse liver tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.