| Product Name | PMAIP1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PMAIP1, NOXA, PMA-induced protein 1, Protein Noxa, APR |
| Product description | Recently, a BH-3 only member of the Bcl-2 family have been identified in human and mouse and designated as Noxa (for damage). The expression of the Noxa gene involves direct activation of its promoter by p53. Increased expression of Noxa protein occurs in normal thymocytes but not in p53-deficient thymocytes. Noxa cDNA codes for a 103-amino acid protein. The coimmunoprecipitation data suggest that Noxa protein may interact with proteins belonging to the Bcl-2 family, such as, Bcl-XL and Mcl-1. Oda et al have also shown that blocking the endogenous Noxa induction results in the suppression of apoptosis. Treatment of cells with Noxa antisense oligonucleotides blocks radiation-induced apoptosis suggesting that Noxa may represent a mediator of p53-dependent apoptosis. |
| Immunogen | PMAIP1 antibody was raised against amino acids 51 - 66 and 75-90 of PMAIP1 (Mouse). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| PMAimmunoprecipitation1 antibody can be used in immunohistochemistry starting at 20 μg/mL, and flow cytometry.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Symbol | PMAIP1 |
|---|---|
| Alternative Names | PMAIP1 NOXA PMA-induced protein 1 Protein Noxa APR |
| Tissue Specificity | Amino acids 51-66 of mouse Noxa are 100% homologous in mouse and 77% in rat; amino acids 75-90 of mouse Noxa are 100% homologous in mouse, 93% homologous in rat and 76% homologous in human. |
| Application Notes | PMAimmunoprecipitation1 antibody can be used in immunohistochemistry starting at 20 μg/mL, and flow cytometry.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | PMAIP1 antibody should be stored long term (months) at -20 ˚C and short term (weeks) at 4 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.05% BSA, 0.05% sodium azide. |
