PMS1 protein homolog 1, DNA mismatch repair protein PMS1, PMS1, PMSL1
Product description
This gene encodes a protein belonging to the DNA mismatch
repair mutL/hexB family. This protein is thought to be involved in
the repair of DNA mismatches, and it can form heterodimers with
MLH1, a known DNA mismatch repair protein. Mutations in this gene
cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3)
either alone or in combination with mutations in other genes
involved in the HNPCC phenotype, which is also known as Lynch
syndrome.1) Hong, K.W., et al. J. Hum. Genet. 55(6):336-341(2010)
Immunogen
This PMS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 694-722 amino acids from the C-terminal region of human PMS1.
Western blot analysis in A549 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.