The protein encoded by this gene is an evolutionarily
conserved protein similar to yeast SSF1 as well as to the gene
product of the Drosophila gene peter pan (ppan). SSF1 is known to
be involved in the second step of mRNA splicing. Both SSF1 and ppan
are essential for cell growth and proliferation. Exogenous
expression of this gene was reported to reduce the
anchorage-independent growth of some tumor cells. Read-through
transcription of this gene with P2RY11/P2Y(11), an adjacent
downstream gene that encodes an ATP receptor, has been found. These
read-through transcripts are ubiquitously present and up-regulated
during granulocyte differentiation.1) Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Immunogen
This PPAN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 422-450 amino acids from the C-terminal region of human PPAN.
Western blot analysis in ZR-75-1 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.