The protein encoded by this gene is a member of the LAR
protein-tyrosine phosphatase-interacting protein (liprin) family.
Liprins interact with members of LAR family of transmembrane
protein tyrosine phosphatases, which are known to be important for
axon guidance and mammary gland development. This protein binds to
the intracellular membrane-distal phosphatase domain of tyrosine
phosphatase LAR, and appears to localize LAR to cell focal
adhesions. This interaction may regulate the disassembly of focal
adhesion and thus help orchestrate cell-matrix interactions.
Alternatively spliced transcript variants encoding distinct
isoforms have been described.1) Asperti, C., et al. Exp. Cell Res. 316(6):915-926(2010)
Immunogen
This PPFIA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-80 amino acids from the N-terminal region of human PPFIA1.
Liprin-alpha-1 LAR-interacting protein 1 LIP-1 Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1 PTPRF-interacting protein alpha-1 PPFIA1 LIP1
Western blot analysis in MDA-MB231 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.