The protein encoded by this gene is a member of the LAR
protein-tyrosine phosphatase-interacting protein (liprin) family.
Liprins interact with members of LAR family of transmembrane
protein tyrosine phosphatases, which are known to be important for
axon guidance and mammary gland development. It has been proposed
that liprins are multivalent proteins that form complex structures
and act as scaffolds for the recruitment and anchoring of LAR
family of tyrosine phosphatases. This protein is most closely
related to PPFIA1, a liprin family member known to interact with
the protein phosphatase LAR. The expression of this gene is found
to be downregulated by androgens in a prostate cancer cell line.1) Rose, J. Phd, et al. Mol. Med. (2010) In press :
Immunogen
This PPFIA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 571-599 amino acids from the Central region of human PPFIA2.
Western blot analysis in mouse liver tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.