Application
Western blot analysis of PRL1 in mouse spleen tissue lysates (35ug/lane)| Product Name | PRL1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Protein tyrosine phosphatase type IVA 1, PTP(CAAXI), Protein-tyrosine phosphatase 4a1, Protein-tyrosine phosphatase of regenerating liver 1, PRL-1, PTP4A1, PRL1, PTPCAAX1 |
| Product description | The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells.PRL phosphatases increase cell proliferation by stimulating progression from G1 into S phase. PRL-1 function is regulated in a cell cycle-dependent manner and implicate PRL-1 in regulating progression through mitosis, possibly by modulating spindle dynamics.1) Jeong,D.G., et al. J. Mol. Biol. 345 (2), 401-413 (2005) |
| Immunogen | This PRL1 antibody is generated from rabbits immunized with a recombinant protein encoding full length of human PRL1. |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| For WB starting dilution is: 1:1000: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Gene Symbol | PTP4A1 |
|---|---|
| Alternative Names | Protein tyrosine phosphatase type IVA 1 PTP(CAAXI) Protein-tyrosine phosphatase 4a1 Protein-tyrosine phosphatase of regenerating liver 1 PRL-1 PTP4A1 PRL1 PTPCAAX1 |
| Molecular Weight(MW) | 20 kDa |
Application
Western blot analysis of PRL1 in mouse spleen tissue lysates (35ug/lane)| Application Notes | For WB starting dilution is: 1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Supplied in PBS with 0.09% (W/V) sodium azide. |
