| Product Name | PRMT6 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PRMT6, Arginine methyltransferase 6, HRMT1L6 |
| Product description | Protein arginine methylation is an important posttranslational modification in eukaryotic cells, which has been implicated in RNA processing and trafficking, receptor-mediated signaling, and transcription. PRMT6 was identified by searching the human genome for protein arginine N-methyltransferase (PRMT) family members. PRMT6 cDNA codes for a protein of approximate molecular weight of 42 kDa consisting of a catalytic core sequence common to other PRMT enzymes. PRMT6 demonstrates type I PRMT activity, capable of forming both >NG-monomethylarginine and asymmetric >NG,NG-dimethylarginine derivatives on the recombinant glycine- and arginine-rich substrates. A comparison of substrate specificity reveals that PRMT6 is functionally distinct from two previously characterized type I enzymes, PRMT1 and PRMT4. In addition to methylating substrate proteins, PRMT6 displays automethylation activit. GFP-fusion protein expression in the transfected cell lines suggest that PRMT6 localizes in the nucleus. |
| Immunogen | PRMT6 antibody was raised against a synthetic peptide of PRMT6 (Human). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ICCIHCWB |
| PRMT6 antibody can be used in Western Blot, immunohistochemistry starting at 10 μg/mL, and flow cytometry.: |
|
| Species Reactivity | HumanMonkey |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Symbol | PRMT6 |
|---|---|
| Alternative Names | PRMT6 Arginine methyltransferase 6 HRMT1L6 |
| Tissue Specificity | Synthetic peptide of human PRMT6. |
| Application Notes | PRMT6 antibody can be used in Western Blot, immunohistochemistry starting at 10 μg/mL, and flow cytometry.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | PRMT6 antibody should be stored long term (months) at -80 ˚C and short term (days) at 4 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.02% sodium azide, 0.1 mg/mL BSA. |
