Application
Antibody used in WB on Human Jurkat 0.2-1 ug/ml.Application
Antibody used in WB on rat, mouse brain extract at 1:500 (Lane 1: 80ug rat brain extract, Lane 2: 80ug mouse brain extract ).Application
Antibody used in IHC on Human kidney.| Product Name | PSEN2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PSEN2, AD3L, AD4, PS2, STM2, CMD1V |
| Product description | Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes.Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified.1) da (2005) Curr Alzheimer Res 2 (5), 507-514. |
| Immunogen | Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PSEN2. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIHCWB |
| PSEN2 antibody can be used for detection of PSEN2 by ELISA at 1:62500. PSEN2 antibody can be used for detection of PSEN2 by western blot at 1.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.: |
|
| Species Reactivity | DogHumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | PSEN2 |
|---|---|
| Alternative Names | PSEN2 AD3L AD4 PS2 STM2 CMD1V |
| Molecular Weight(MW) | 49 kDa, 50 kDa |
Application
Antibody used in WB on Human Jurkat 0.2-1 ug/ml.
Application
Antibody used in WB on rat, mouse brain extract at 1:500 (Lane 1: 80ug rat brain extract, Lane 2: 80ug mouse brain extract ).
Application
Antibody used in IHC on Human kidney.| Positive Control | 1) Cat. No. 1205 - Jurkat Cell Lysate |
|---|---|
| Application Notes | PSEN2 antibody can be used for detection of PSEN2 by ELISA at 1:62500. PSEN2 antibody can be used for detection of PSEN2 by western blot at 1.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.: |
| Form | Liquid |
|---|---|
| Storage Instructions | For short periods of storage (days) store at 4˚C. For longer periods of storage, store PSEN2 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles. |
| Storage Buffer | Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL. |
