Application
Western blot analysis of lysates from Hela, MCF-7 cell line (from left to right), using PSEN2(Presenilin-2 CTF subunit) Antibody at 1:1000 at each lane.Application
Immunohistochemical analysis of paraffin-embedded H.heart section using PSEN2(Presenilin-2 CTF subunit) Antibody . Antibody was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.Application
Immunohistochemical analysis of paraffin-embedded R.heart section using PSEN2(Presenilin-2 CTF subunit) Antibody . Antibody was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.Application
Immunohistochemical analysis of paraffin-embedded M.heart section using PSEN2(Presenilin-2 CTF subunit) Antibody . Antibody was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.| Product Name | PSEN2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Presenilin-2, PS-2, 3423-, AD3LP, AD5, E5-1, STM-2, Presenilin-2 NTF subunit, Presenilin-2 CTF subunit, PSEN2, AD4, PS2, PSNL2, STM2 |
| Product description | Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.1) Levy-Lahad E.,et al.Science 269:973-977(1995). |
| Immunogen | This PSEN2(Presenilin-2 CTF subunit) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 401-445 amino acids from the C-terminal region of human PSEN2(Presenilin-2 CTF subunit). |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | IHC-PWB |
| For IHC-P starting dilution is: 1:25 For WB starting dilution is: 1:1000: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | PSEN2 |
|---|---|
| Alternative Names | Presenilin-2 PS-2 3423- AD3LP AD5 E5-1 STM-2 Presenilin-2 NTF subunit Presenilin-2 CTF subunit PSEN2 AD4 PS2 PSNL2 STM2 |
| Molecular Weight(MW) | 50 kDa |
| Sequence Similarities | Predicted species reactivity based on immunogen sequence: Bovine |
Application
Western blot analysis of lysates from Hela, MCF-7 cell line (from left to right), using PSEN2(Presenilin-2 CTF subunit) Antibody at 1:1000 at each lane.
Application
Immunohistochemical analysis of paraffin-embedded H.heart section using PSEN2(Presenilin-2 CTF subunit) Antibody . Antibody was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
Application
Immunohistochemical analysis of paraffin-embedded R.heart section using PSEN2(Presenilin-2 CTF subunit) Antibody . Antibody was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
Application
Immunohistochemical analysis of paraffin-embedded M.heart section using PSEN2(Presenilin-2 CTF subunit) Antibody . Antibody was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.| Application Notes | For IHC-P starting dilution is: 1:25 For WB starting dilution is: 1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Supplied in PBS with 0.09% (W/V) sodium azide. |
