Application
Immunohistochemistry staining of ATRX in kidney tissue using ATRX monoclonal Antibody.| Product Name | RAD54L Antibody [60.1] |
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| Antibody Type | Primary Antibodies |
| Product description | The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (RAD54L) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Immunogen | RAD54L monoclonal antibody was raised against a combination of N & C peptide, corresponding to a range between amino acids 1-300 and 450-741 |
| Clonality | Monoclonal |
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| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | ELISAIHCWB |
| RAD54L antibody can be used in ELISA, and immunohistochemistry starting at 10 μg/mL. | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Symbol | RAD54L |
|---|---|
| Alternative Names | RAD54L ATP-dependent helicase RAD54L ATR2 Juberg-Marsidi syndrome JMS RAD54 RAD54 homolog SFM1 MRXHF1 XH2 XNP Transcriptional regulator RAD54L ZNF-HX X-linked nuclear protein SHS Helicase 2 X-linked X-linked helicase II Zinc finger helica |
Application
Immunohistochemistry staining of ATRX in kidney tissue using ATRX monoclonal Antibody.| Application Notes | RAD54L antibody can be used in ELISA, and immunohistochemistry starting at 10 μg/mL. |
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| Form | Liquid |
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| Storage Instructions | Store RAD54L antibody at -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, pH 7.2. No preservatives added. |
