The transport of protein and large RNAs through the
nuclear pore complexes (NPC) is an energy-dependent and regulated
process. The import of proteins with a nuclear localization signal
(NLS) is accomplished by recognition of one or more clusters of
basic amino acids by the importin-alpha/beta complex; see MIM
600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a
key role in NLS-dependent protein import. RAN-binding protein-17 is
a member of the importin-beta superfamily of nuclear transport
receptors.1) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Immunogen
This RANBP17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-175 amino acids from the N-terminal region of human RANBP17.
Western blot analysis in mouse testis tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.